A new modification of anti-tubercular active molecules
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
17306980
DOI
10.1016/j.bmc.2007.01.051
PII: S0968-0896(07)00077-6
Knihovny.cz E-resources
- MeSH
- Antitubercular Agents chemical synthesis chemistry pharmacology MeSH
- Chemical Phenomena MeSH
- Chemistry, Physical MeSH
- Isoniazid chemical synthesis pharmacology MeSH
- Kinetics MeSH
- Quantitative Structure-Activity Relationship MeSH
- Lipids chemistry MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium avium drug effects MeSH
- Mycobacterium kansasii drug effects MeSH
- Half-Life MeSH
- Pyrazinamide chemical synthesis pharmacology MeSH
- Chromatography, High Pressure Liquid MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Antitubercular Agents MeSH
- Isoniazid MeSH
- Lipids MeSH
- Pyrazinamide MeSH
The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed.
References provided by Crossref.org
N-substituted 2-isonicotinoylhydrazinecarboxamides--new antimycobacterial active molecules
