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PubMed

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Treatment of orthopedic infections caused by resistant staphylococci

Folia microbiologica. 2007 ; 52 (3) : 281-5.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Language English Country United States Media print

Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid17702467

PubMed 17702467
DOI 10.1007/bf02931310
Knihovny.cz E-resources

MeSH
Acetamides therapeutic use MeSH
Anti-Infective Agents therapeutic use MeSH
Adult MeSH
Prosthesis-Related Infections drug therapy microbiology MeSH
Middle Aged MeSH
Humans MeSH
Linezolid MeSH
Microbial Sensitivity Tests MeSH
Osteomyelitis drug therapy microbiology MeSH
Oxazolidinones therapeutic use MeSH
Methicillin Resistance drug effects MeSH
Aged MeSH
Staphylococcal Infections drug therapy MeSH
Staphylococcus aureus drug effects MeSH
Treatment Outcome MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Clinical Trial MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Acetamides MeSH
Anti-Infective Agents MeSH
Linezolid MeSH
Oxazolidinones MeSH

During 1999-2005 we treated 15 patients with linezolid for relevant infections of locomotion apparatus (7 cases with endoprosthesis infection, 5x osteomyelitis and 3x another infection). With the exception of one case the antibiotic therapy was always combined with appropriate surgical intervention. Average period of linezolid administration was 26 d; linezolid was applied from the beginning intravenously on average for 10 d, and then orally for 16 d (average). There were no undesirable effects in the file. Success rate reached 86.6%. MRSA strains were proved by standard methods: growth on Mueller-Hinton agar with increased concentration of NaCl and 2 mg/L of oxacilline, and measuring inhibitory zones around cephoxitine disk. The sensitivity to other antibiotics was specified by disk-diffusion test; that to linezolid was verified by E-test. Linezolid represents a medical reserve for the treatment of multiresistant Gram-positive infections or for emergencies, when allergy onset, high toxicity risk, intolerance, etc. do not allow to use other, in vitro effective, antibiotics.

1st Orthopedic Clinic 1st Medical Faculty Charles University 150 06 Prague Czechia

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