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14-3-3 proteins: a family of versatile molecular regulators

. 2008 ; 57 Suppl 3 () : S11-21. [epub] 20080513

Language English Country Czech Republic Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.

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