14-3-3 proteins: a family of versatile molecular regulators
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18481918
DOI
10.33549/physiolres.931598
PII: 1598
Knihovny.cz E-resources
- MeSH
- Forkhead Transcription Factors metabolism MeSH
- Protein Conformation MeSH
- Conserved Sequence MeSH
- Protein Structure, Quaternary MeSH
- Humans MeSH
- Models, Molecular MeSH
- Molecular Sequence Data MeSH
- Protein Isoforms MeSH
- 14-3-3 Proteins chemistry genetics metabolism MeSH
- Amino Acid Sequence MeSH
- Tyrosine 3-Monooxygenase metabolism MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Forkhead Transcription Factors MeSH
- Protein Isoforms MeSH
- 14-3-3 Proteins MeSH
- Tyrosine 3-Monooxygenase MeSH
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
References provided by Crossref.org
Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins
SIRT1 Modulators in Experimentally Induced Liver Injury
