Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
19060591
DOI
10.1097/coc.0b013e318174dbb9
PII: 00000421-200812000-00010
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Gastrointestinal Stromal Tumors complications drug therapy pathology MeSH
- Intestinal Absorption * MeSH
- Lactulose urine MeSH
- Middle Aged MeSH
- Humans MeSH
- Mannitol urine MeSH
- Young Adult MeSH
- Rectal Neoplasms complications drug therapy pathology MeSH
- Permeability MeSH
- Prognosis MeSH
- Antineoplastic Combined Chemotherapy Protocols adverse effects MeSH
- Diarrhea chemically induced drug therapy metabolism MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Vitamin A metabolism MeSH
- Xylose urine MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Lactulose MeSH
- Mannitol MeSH
- Vitamin A MeSH
- Xylose MeSH
OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.
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