Antioxidative enzymes and increased oxidative stress in depressive women
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
19527700
DOI
10.1016/j.clinbiochem.2009.06.006
PII: S0009-9120(09)00257-4
Knihovny.cz E-zdroje
- MeSH
- alkadieny krev chemie MeSH
- aryldialkylfosfatasa krev metabolismus MeSH
- depresivní poruchy krev enzymologie patologie MeSH
- enzymy krev metabolismus MeSH
- glutathion krev metabolismus MeSH
- glutathionperoxidasa krev metabolismus MeSH
- glutathionreduktasa krev metabolismus MeSH
- katalasa krev metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidace-redukce MeSH
- oxidační stres * MeSH
- senioři MeSH
- spektrofotometrie MeSH
- superoxiddismutasa krev metabolismus MeSH
- triglyceridy krev MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- alkadieny MeSH
- aryldialkylfosfatasa MeSH
- enzymy MeSH
- glutathion MeSH
- glutathionperoxidasa MeSH
- glutathionreduktasa MeSH
- katalasa MeSH
- PON1 protein, human MeSH Prohlížeč
- superoxiddismutasa MeSH
- triglyceridy MeSH
OBJECTIVES: To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD). METHODS: In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated. RESULTS: Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01). CONCLUSION: Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.
Citace poskytuje Crossref.org
Altered activities of antioxidant enzymes in patients with metabolic syndrome