Antioxidative enzymes and increased oxidative stress in depressive women
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19527700
DOI
10.1016/j.clinbiochem.2009.06.006
PII: S0009-9120(09)00257-4
Knihovny.cz E-resources
- MeSH
- Alkadienes blood chemistry MeSH
- Aryldialkylphosphatase blood metabolism MeSH
- Depressive Disorder blood enzymology pathology MeSH
- Enzymes blood metabolism MeSH
- Glutathione blood metabolism MeSH
- Glutathione Peroxidase blood metabolism MeSH
- Glutathione Reductase blood metabolism MeSH
- Catalase blood metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Oxidation-Reduction MeSH
- Oxidative Stress * MeSH
- Aged MeSH
- Spectrophotometry MeSH
- Superoxide Dismutase blood metabolism MeSH
- Triglycerides blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkadienes MeSH
- Aryldialkylphosphatase MeSH
- Enzymes MeSH
- Glutathione MeSH
- Glutathione Peroxidase MeSH
- Glutathione Reductase MeSH
- Catalase MeSH
- PON1 protein, human MeSH Browser
- Superoxide Dismutase MeSH
- Triglycerides MeSH
OBJECTIVES: To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD). METHODS: In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated. RESULTS: Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01). CONCLUSION: Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.
References provided by Crossref.org
Altered activities of antioxidant enzymes in patients with metabolic syndrome
