Osteogenic cells on bio-inspired materials for bone tissue engineering
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
19681662
DOI
10.33549/physiolres.931776
PII: 931776
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials * MeSH
- Bone Substitutes chemistry therapeutic use MeSH
- Humans MeSH
- Osteoblasts physiology MeSH
- Osteogenesis * MeSH
- Osseointegration * MeSH
- Surface Properties MeSH
- Prosthesis Design MeSH
- Tissue Engineering * MeSH
- Bone Transplantation instrumentation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biocompatible Materials * MeSH
- Bone Substitutes MeSH
This article reviews the development of artificial bone substitutes from their older single-phase forms to novel multi-phase composites, mimicking the composition and architecture of natural bone tissue. The new generation of bone implants should be bioactive, i.e. they should induce the desired cellular responses, leading to integration of the material into the natural tissue and stimulating self-healing processes. Therefore, the first part of the review explains the common principles of the cell-material interaction and summarizes the strategies how to improve the biocompatibility and bioactivity of the materials by modifying the physico-chemical properties of the material surface, such as surface chemistry, wettability, electrical charge, rigidity, microroughness and especially nanoroughness. The latter has been shown to stimulate preferentially the growth of osteoblasts in comparison with other competitive cell types, such as fibroblasts, which could prevent fibrous tissue formation upon implantation. The second more specialized part of the review deals with materials suitable for bone contact and substitution, particularly novel polymer-based composites reinforced with fibres or inorganic particles and containing bioactive components, such as crystals of hydroxyapatite or other calcium phosphates, synthetic ligands for cell adhesion receptors or growth factors. Moreover, if they are degradable, they can be gradually replaced with a regenerating tissue.
References provided by Crossref.org
Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer
Novel Approach in the Use of Plasma Spray: Preparation of Bulk Titanium for Bone Augmentations
Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films