Paliperidon mediated modification of cortical inhibition
Language English Country Sweden Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19855366
PII: NEL300309A11
Knihovny.cz E-resources
- MeSH
- Antipsychotic Agents administration & dosage MeSH
- Diagnostic and Statistical Manual of Mental Disorders MeSH
- Adult MeSH
- Electromyography MeSH
- Isoxazoles administration & dosage MeSH
- Humans MeSH
- Evoked Potentials, Motor drug effects MeSH
- Cerebral Cortex drug effects MeSH
- Neural Inhibition drug effects MeSH
- Paliperidone Palmitate MeSH
- Schizophrenia, Paranoid diagnosis drug therapy MeSH
- Pyrimidines administration & dosage MeSH
- Transcranial Magnetic Stimulation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antipsychotic Agents MeSH
- Isoxazoles MeSH
- Paliperidone Palmitate MeSH
- Pyrimidines MeSH
Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABA(B) receptors, we can assume that paliperidone may have the ability to enhance GABA(B) receptor-mediated neurotransmission.
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