Cerebrospinal fluid and serum antibodies against neurofilaments in patients with amyotrophic lateral sclerosis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19968709
DOI
10.1111/j.1468-1331.2009.02853.x
PII: ENE2853
Knihovny.cz E-resources
- MeSH
- Amyotrophic Lateral Sclerosis blood cerebrospinal fluid immunology MeSH
- Autoantibodies blood cerebrospinal fluid MeSH
- Time Factors MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Immunoglobulin G blood cerebrospinal fluid MeSH
- Middle Aged MeSH
- Humans MeSH
- Neurofilament Proteins immunology MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Severity of Illness Index MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Immunoglobulin G MeSH
- neurofilament protein L MeSH Browser
- neurofilament protein M MeSH Browser
- Neurofilament Proteins MeSH
BACKGROUND: The aim of the study was to assess autoimmune involvement in amyotrophic lateral sclerosis (ALS). METHODS: We measured IgG antibodies against light (NFL) and medium (NFM) subunits of neurofilaments using ELISA in paired cerebrospinal fluid (CSF) and serum samples from 38 ALS patients and 20 controls. RESULTS: Serum levels of anti-NFL were higher in ALS patients than in controls (P < 0.005). Serum anti-NFL antibodies and intrathecal anti-NFM antibodies were related to patient disability (serum anti-NFL: P < 0.05; intrathecal anti-NFM: P < 0.05). Anti-NFL levels were significantly correlated with anti-NFM levels in ALS (P < 0.001) and the control group (P < 0.0001) in the CSF, but not in serum. Anti-NFL and anti-NFM antibodies significantly correlated between serum and CSF in the ALS group (anti-NFL: P < 0.0001; anti-NFM: P < 0.001) and in the control group (anti-NFL: P < 0.05; anti-NFM: P < 0.05). CONCLUSIONS: Autoimmune humoral response to neurocytoskeletal proteins is associated with ALS.
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