CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20359956
DOI
10.1016/j.clim.2010.03.005
PII: S1521-6616(10)00087-2
Knihovny.cz E-resources
- MeSH
- Autoantigens pharmacology MeSH
- Autoimmune Diseases immunology MeSH
- Autoantibodies blood immunology MeSH
- Killer Cells, Natural cytology drug effects immunology metabolism MeSH
- Cytotoxicity, Immunologic drug effects immunology MeSH
- Dermatomyositis immunology MeSH
- Adult MeSH
- Gene Expression drug effects genetics MeSH
- Glucocorticoids therapeutic use MeSH
- Glycoconjugates pharmacology MeSH
- Hydrolases genetics MeSH
- Immunosuppressive Agents therapeutic use MeSH
- NK Cell Lectin-Like Receptor Subfamily B agonists genetics metabolism MeSH
- Leukocytes, Mononuclear cytology drug effects immunology metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- N-Acetylglucosaminyltransferases genetics MeSH
- Osteoarthritis immunology MeSH
- Protein-Arginine Deiminase Type 4 MeSH
- Protein-Arginine Deiminases MeSH
- Cell Count MeSH
- Polymyositis immunology MeSH
- Polysaccharides pharmacology MeSH
- Arthritis, Rheumatoid diagnosis drug therapy immunology MeSH
- Aged MeSH
- Synovial Fluid cytology metabolism MeSH
- Vimentin pharmacology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase MeSH Browser
- Autoantigens MeSH
- Autoantibodies MeSH
- Glucocorticoids MeSH
- Glycoconjugates MeSH
- Hydrolases MeSH
- Immunosuppressive Agents MeSH
- NK Cell Lectin-Like Receptor Subfamily B MeSH
- N-Acetylglucosaminyltransferases MeSH
- PADI4 protein, human MeSH Browser
- Protein-Arginine Deiminase Type 4 MeSH
- Protein-Arginine Deiminases MeSH
- Polysaccharides MeSH
- Vimentin MeSH
We investigated the role of natural killer (NK) cells and CD161, their primary C-type-lectin-like receptor in rheumatoid arthritis (RA). Samples were compared with healthy donors (HD), dermatomyositic (DM), polymyositic (PM), and osteoarthritic (OA) patients. RA, PM, and DM NK cell cytotoxicities significantly decreased relative to the HD and OA NK cells (p<0.0001). These results correlated with an increased expression of NK cell inhibitory receptor CD161, in active disease RA patients. We demonstrated that NK cells are able to respond to mutated citrullinated vimentin (MCV), an RA-specific autoantigen, leading to increases in both PAD4 enzyme and CD161 mRNA expression. MGAT5 glycosidase involvement was detected in GlcNAc metabolism within the synoviocytes of RA patients. Our findings reveal a functional relationship between CD161 expression and NK cell cytotoxicity as well as reactivity to glycans and MCV, thus providing new insight into the pathogenesis of RA and confirming the involvement of surface glycosylation.
Clin Immunol. 2015 Mar;157(1):102 PubMed
References provided by Crossref.org
