Polyoxazoline thermoresponsive micelles as radionuclide delivery systems
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Hemolysis MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Micelles * MeSH
- Molecular Weight MeSH
- Oxazoles chemistry MeSH
- Polymers chemistry MeSH
- Radioisotopes administration & dosage MeSH
- Temperature MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Micelles * MeSH
- Oxazoles MeSH
- poly(2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline) MeSH Browser
- Polymers MeSH
- Radioisotopes MeSH
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 × 10(-5) g · mL(-1) with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.
References provided by Crossref.org
Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers
Fluorine polymer probes for magnetic resonance imaging: quo vadis?
Investigation of drug release modulation from poly(2-oxazoline) micelles through ultrasound
