Polyoxazoline thermoresponsive micelles as radionuclide delivery systems
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20491128
DOI
10.1002/mabi.201000034
Knihovny.cz E-zdroje
- MeSH
- hemolýza MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- micely * MeSH
- molekulová hmotnost MeSH
- oxazoly chemie MeSH
- polymery chemie MeSH
- radionuklidy aplikace a dávkování MeSH
- teplota MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- micely * MeSH
- oxazoly MeSH
- poly(2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline) MeSH Prohlížeč
- polymery MeSH
- radionuklidy MeSH
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5-10 × 10(-5) g · mL(-1) with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.
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