Incidence, severity, and etiology of drug-induced acute pancreatitis
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- akutní nemoc MeSH
- azathioprin škodlivé účinky MeSH
- Crohnova nemoc farmakoterapie epidemiologie MeSH
- cytarabin škodlivé účinky MeSH
- dexamethason škodlivé účinky MeSH
- dítě MeSH
- dospělí MeSH
- imunosupresiva škodlivé účinky MeSH
- incidence MeSH
- kyselina mykofenolová škodlivé účinky analogy a deriváty MeSH
- kyselina valproová škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- mesalamin škodlivé účinky MeSH
- mladiství MeSH
- mladý dospělý MeSH
- pankreatitida chemicky indukované epidemiologie MeSH
- předškolní dítě MeSH
- ramipril škodlivé účinky MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stupeň závažnosti nemoci * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- azathioprin MeSH
- cytarabin MeSH
- dexamethason MeSH
- imunosupresiva MeSH
- kyselina mykofenolová MeSH
- kyselina valproová MeSH
- mesalamin MeSH
- ramipril MeSH
INTRODUCTION: Drug-induced acute pancreatitis is considered to be a rare diagnosis. The incidence of drug-induced acute pancreatitis is usually estimated from case reports. AIM: The aim of this study was to determine the incidence, etiology, and severity of drug-induced pancreatitis during a 2-year period in a tertiary hospital. METHODS: The study was conducted as a retrospective analysis of all cases of pancreatitis in the University Hospital in Olomouc (1,432 beds) in 2006-2007. All cases of acute pancreatitis were re-evaluated and divided according to the causative factor. In drug-induced cases, the WHO Probability Scale for the evaluation of causality relationship was used. RESULTS: The inclusion criteria were met by 170 medical files. There were 91 (53%) cases in men and 79 (47%) in women, and mean age was 57 years old (5-91 years old). The etiology was in 53% biliary, 31% alcohol-induced, 12% other determined, and in 4% the cause could not be established. The proportion of drug-induced acute pancreatitis was 5.3% and it was the third most frequent cause of the AP. Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate. CONCLUSIONS: The diagnosis of drug-induced acute pancreatitis seems to be underestimated because of the difficulties in determining the causative agent and the need for a retrospective re-evaluation of the suspected causative factors. The disease is more probable in younger persons, women, and patients suffering from Crohn's disease.
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