Incidence, severity, and etiology of drug-induced acute pancreatitis
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acute Disease MeSH
- Azathioprine adverse effects MeSH
- Crohn Disease drug therapy epidemiology MeSH
- Cytarabine adverse effects MeSH
- Dexamethasone adverse effects MeSH
- Child MeSH
- Adult MeSH
- Immunosuppressive Agents adverse effects MeSH
- Incidence MeSH
- Mycophenolic Acid adverse effects analogs & derivatives MeSH
- Valproic Acid adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Mesalamine adverse effects MeSH
- Adolescent MeSH
- Young Adult MeSH
- Pancreatitis chemically induced epidemiology MeSH
- Child, Preschool MeSH
- Ramipril adverse effects MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Severity of Illness Index * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Azathioprine MeSH
- Cytarabine MeSH
- Dexamethasone MeSH
- Immunosuppressive Agents MeSH
- Mycophenolic Acid MeSH
- Valproic Acid MeSH
- Mesalamine MeSH
- Ramipril MeSH
INTRODUCTION: Drug-induced acute pancreatitis is considered to be a rare diagnosis. The incidence of drug-induced acute pancreatitis is usually estimated from case reports. AIM: The aim of this study was to determine the incidence, etiology, and severity of drug-induced pancreatitis during a 2-year period in a tertiary hospital. METHODS: The study was conducted as a retrospective analysis of all cases of pancreatitis in the University Hospital in Olomouc (1,432 beds) in 2006-2007. All cases of acute pancreatitis were re-evaluated and divided according to the causative factor. In drug-induced cases, the WHO Probability Scale for the evaluation of causality relationship was used. RESULTS: The inclusion criteria were met by 170 medical files. There were 91 (53%) cases in men and 79 (47%) in women, and mean age was 57 years old (5-91 years old). The etiology was in 53% biliary, 31% alcohol-induced, 12% other determined, and in 4% the cause could not be established. The proportion of drug-induced acute pancreatitis was 5.3% and it was the third most frequent cause of the AP. Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate. CONCLUSIONS: The diagnosis of drug-induced acute pancreatitis seems to be underestimated because of the difficulties in determining the causative agent and the need for a retrospective re-evaluation of the suspected causative factors. The disease is more probable in younger persons, women, and patients suffering from Crohn's disease.
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