Toxoplasma gondii strain-dependent effects on mouse behaviour
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
DC000232
NIDCD NIH HHS - United States
PubMed
20608478
DOI
10.14411/fp.2010.019
Knihovny.cz E-resources
- MeSH
- Behavior, Animal * MeSH
- Cats urine MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Odorants MeSH
- Toxoplasma classification MeSH
- Toxoplasmosis, Animal psychology MeSH
- Animals MeSH
- Check Tag
- Cats urine MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
Toxoplasma gondii reportedly manipulates rodent behaviour to increase transmission to its definitive feline host. We compared the effects of mouse infection by two Type II strains of T. gondii, Prugniaud (PRU) and ME49, on attraction to cat odour, locomotor activity, anxiety, sensorimotor gating, and spatial working and recognition memory 2 months post-infection (mpi). Attraction to cat odour was reassessed 7 mpi. At 2 mpi, mice infected with either strain exhibited significantly more attraction to cat odour than uninfected animals did, but only PRU-infected mice exhibited this behaviour 7 mpi. PRU-infected mice had significantly greater body weights and hyperactivity, while ME49-infected mice exhibited impaired spatial working memory. No differences in parasite antibody titres were seen between PRU- and ME49-infected mice. The present data suggest the effect of T. gondii infection on mouse behaviour is parasite strain-dependent.
References provided by Crossref.org
