Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
20880411
DOI
10.1111/j.1469-0691.2010.03237.x
PII: S1198-743X(14)61735-3
Knihovny.cz E-zdroje
- MeSH
- bakteriální léková rezistence MeSH
- bakteriální polysacharidy fyziologie MeSH
- Burkholderia cenocepacia klasifikace genetika izolace a purifikace patogenita MeSH
- Burkholderia cepacia komplex klasifikace genetika izolace a purifikace patogenita MeSH
- cystická fibróza genetika mikrobiologie MeSH
- exprese genu MeSH
- infekce bakteriemi rodu Burkholderia komplikace epidemiologie mikrobiologie MeSH
- infekce dýchací soustavy komplikace epidemiologie mikrobiologie MeSH
- lidé MeSH
- molekulární epidemiologie MeSH
- multilokusová sekvenční typizace metody MeSH
- mutace MeSH
- quorum sensing MeSH
- rozptýlené repetitivní sekvence MeSH
- virulence genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Geografické názvy
- Evropa epidemiologie MeSH
- Kanada epidemiologie MeSH
- Názvy látek
- bakteriální polysacharidy MeSH
Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat, and also have the ability to spread between CF individuals. Of the 17 formally named species within the complex, Burkholderia multivorans and Burkholderia cenocepacia dominate in CF. Multilocus sequence typing has proven to be a very useful tool for tracing the global epidemiology of Bcc bacteria and has shown that B. cenocepacia strains with high transmissibility, such as the ET-12 strain (ST-28) and the Czech strain (ST-32), have spread epidemically within CF populations in Canada and Europe. The majority of research on the molecular pathogenesis of Bcc bacteria has focused on the B. cenocepacia ET-12 epidemic lineage, with gene mutation, genome sequence analysis and, most recently, global gene expression studies shedding considerable light on the virulence and antimicrobial resistance of this pathogen. These studies demonstrate that the ability of B. cenocepacia to acquire foreign DNA (genomic islands, insertion sequences and other mobile elements), regulate gene expression via quorum sensing, compete for iron during infection, and mediate antimicrobial resistance and inflammation via its membrane and surface polysaccharides are key features that underpin the virulence of different strains. With the wealth of molecular knowledge acquired in the last decade on B. cenocepacia strains, we are now in a much better position to develop strategies for the treatment of pathogenic colonization with Bcc and to answer key questions on pathogenesis concerning, for example, the factors that trigger the rapid clinical decline in CF patients.
Citace poskytuje Crossref.org
Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis