Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21130691
DOI
10.1016/j.yebeh.2010.10.021
PII: S1525-5050(10)00668-2
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Quinolizines pharmacology MeSH
- GABA Modulators pharmacology MeSH
- Clonazepam pharmacology MeSH
- Rats MeSH
- Disease Susceptibility chemically induced MeSH
- Animals, Newborn MeSH
- Pentylenetetrazole MeSH
- Motor Activity drug effects MeSH
- Rats, Wistar MeSH
- Pyrrolidines pharmacology MeSH
- Receptors, GABA-A metabolism MeSH
- Vocalization, Animal drug effects MeSH
- Seizures chemically induced metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Quinolizines MeSH
- GABA Modulators MeSH
- Clonazepam MeSH
- Pentylenetetrazole MeSH
- Pyrrolidines MeSH
- Receptors, GABA-A MeSH
- Ro 19-8022 MeSH Browser
The purpose of our study was to determine whether a single administration of anticonvulsant doses of two ligands of benzodiazepine receptors, clonazepam and Ro 19-8022, leads to development of rebound phenomena in immature 12-day-old rats. Three tests were used: pentylenetetrazole (PTZ)-induced seizures, isolation-induced ultrasonic vocalizations, and motor performance. Susceptibility to the convulsant effects of PTZ decreased 24 hours, but increased 48 hours, after clonazepam administration. Ultrasonic vocalizations were completely suppressed 30 minutes and 3 hours after clonazepam; a moderate inhibitory effect persisted even at 48 hours. Motor abilities were slightly compromised up to 3 hours. Similar effects of Ro 19-8022 on PTZ-induced seizures and ultrasonic vocalizations were observed 24 and 48 hours after administration; motor performance was not affected. Rebound proconvulsant effects followed different time courses after administration of the two benzodiazepine receptor ligands in developing animals. Anxiolytic-like effects of these drugs were still present at the time when animals exhibited rebound proconvulsant effects.
Epilepsy Behav. 2012 Mar;23(3):398 PubMed
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
The outcome of early life status epilepticus-lessons from laboratory animals
Neonatal Clonazepam Administration Induced Long-Lasting Changes in GABAA and GABAB Receptors
Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors
Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
Consequences of early postnatal benzodiazepines exposure in rats. I. Cognitive-like behavior
