Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21395538
DOI
10.2174/138920011795016818
PII: BSP/CDM/E-Pub/000128
Knihovny.cz E-resources
- MeSH
- Humans MeSH
- Ligands * MeSH
- Molecular Structure MeSH
- Receptors, Aryl Hydrocarbon agonists antagonists & inhibitors physiology MeSH
- Xenobiotics chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Ligands * MeSH
- Receptors, Aryl Hydrocarbon MeSH
- Xenobiotics MeSH
Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 family genes and some phase II enzymes. AhR also has many endogenous functions including cell cycle control, immune response, and cell differentiation. In addition, AhR is well-known to be involved in chemically-induced carcinogenesis. AhR is activated by a variety of endogenous and exogenous ligands. While exogenous activation of AhR has deleterious effects on human organism, sustained activation of AhR by endogenous ligands is indispensable for proper cell functions. Therefore, the effects of exogenous and endogenous ligands on AhR resemble the Dr. Jekyll and Mr. Hyde story. The aim of the current paper is to summarize and update the knowledge on exogenous and endogenous AhR ligands.
References provided by Crossref.org
Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor
