Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- buněčná diferenciace MeSH
- buněčné extrakty chemie MeSH
- buněčné kultury MeSH
- dipeptidylpeptidasa 4 genetika metabolismus MeSH
- endopeptidasy MeSH
- enzymatické testy MeSH
- genetická transkripce * MeSH
- lidé MeSH
- membránové proteiny genetika metabolismus MeSH
- messenger RNA genetika metabolismus MeSH
- neuroglie enzymologie metabolismus MeSH
- rekombinantní proteiny genetika metabolismus MeSH
- serinové endopeptidasy genetika metabolismus MeSH
- transformované buněčné linie MeSH
- želatinasy genetika metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- buněčné extrakty MeSH
- dipeptidylpeptidasa 4 MeSH
- endopeptidasy MeSH
- fibroblast activation protein alpha MeSH Prohlížeč
- membránové proteiny MeSH
- messenger RNA MeSH
- rekombinantní proteiny MeSH
- serinové endopeptidasy MeSH
- želatinasy MeSH
Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein-α (FAP) are speculated to participate in the regulation of multiple biological processes, because of their unique enzymatic activity, as well as by non-hydrolytic molecular interactions. At present, the role of DPP-IV and FAP in the development and progression of various types of tumors, including glioblastoma, is intensively studied, and their functional crosstalk is hypothesized. In this article, we describe the correlative expression of DPP-IV and FAP mRNA in primary cell cultures derived from human glioblastoma and associated expression dynamics of both molecules in astrocytoma cell lines depending on culture conditions. Although the molecular mechanisms of DPP-IV and FAP co-regulations remain unclear, uncoupled expression of transgenic DPP-IV and the endogenous FAP suggests that it occurs rather at the transcriptional than at the posttranscriptional level. Understanding of the expressional and functional coordinations of DPP-IV and FAP may help clarify the mechanisms of biological roles of both molecules in transformed astrocytic cells.
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