Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-α in transformed astrocytic cells
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cell Differentiation MeSH
- Cell Extracts chemistry MeSH
- Cell Culture Techniques MeSH
- Dipeptidyl Peptidase 4 genetics metabolism MeSH
- Endopeptidases MeSH
- Enzyme Assays MeSH
- Transcription, Genetic * MeSH
- Humans MeSH
- Membrane Proteins genetics metabolism MeSH
- RNA, Messenger genetics metabolism MeSH
- Neuroglia enzymology metabolism MeSH
- Recombinant Proteins genetics metabolism MeSH
- Serine Endopeptidases genetics metabolism MeSH
- Cell Line, Transformed MeSH
- Gelatinases genetics metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cell Extracts MeSH
- Dipeptidyl Peptidase 4 MeSH
- Endopeptidases MeSH
- fibroblast activation protein alpha MeSH Browser
- Membrane Proteins MeSH
- RNA, Messenger MeSH
- Recombinant Proteins MeSH
- Serine Endopeptidases MeSH
- Gelatinases MeSH
Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein-α (FAP) are speculated to participate in the regulation of multiple biological processes, because of their unique enzymatic activity, as well as by non-hydrolytic molecular interactions. At present, the role of DPP-IV and FAP in the development and progression of various types of tumors, including glioblastoma, is intensively studied, and their functional crosstalk is hypothesized. In this article, we describe the correlative expression of DPP-IV and FAP mRNA in primary cell cultures derived from human glioblastoma and associated expression dynamics of both molecules in astrocytoma cell lines depending on culture conditions. Although the molecular mechanisms of DPP-IV and FAP co-regulations remain unclear, uncoupled expression of transgenic DPP-IV and the endogenous FAP suggests that it occurs rather at the transcriptional than at the posttranscriptional level. Understanding of the expressional and functional coordinations of DPP-IV and FAP may help clarify the mechanisms of biological roles of both molecules in transformed astrocytic cells.
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