GABA-A receptors play a minor role in cortical epileptic afterdischarges in immature rats
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21824607
DOI
10.1016/j.brainres.2011.07.034
PII: S0006-8993(11)01319-9
Knihovny.cz E-resources
- MeSH
- Bicuculline pharmacology MeSH
- Electric Stimulation MeSH
- Evoked Potentials drug effects physiology MeSH
- GABA Antagonists pharmacology MeSH
- Electrodes, Implanted MeSH
- Rats MeSH
- Cerebral Cortex drug effects physiopathology MeSH
- Rats, Wistar MeSH
- Receptors, GABA-A physiology MeSH
- Seizures physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bicuculline MeSH
- GABA Antagonists MeSH
- Receptors, GABA-A MeSH
The role of inhibitory γ-aminobutyric acid-A (GABA-A) system in the cortical epileptic afterdischarges (ADs) was studied at three different developmental stages of rats. Animals 12, 18 and 25days old with implanted epidural electrodes were pretreated with bicuculline (1 and 2mg/kgi.p.) and 15min later repeatedly stimulated with low frequency trains with stepwise increasing current intensity. Bicuculline only exceptionally decreased threshold current intensities necessary for elicitation of movements directly bound to stimulation, spike-and wave ADs, clonic seizures and transition into a limbic type of ADs. Duration of ADs was not systematically affected by either dose of bicuculline. In contrast, transcallosal evoked potentials exhibited under the influence of bicuculline steeper curve expressing relation between intensity of stimuli and amplitude of responses. In contrast to GABA-B receptors, GABA-A receptors do not play an important role in generation and arrest of cortical epileptic ADs in immature rats.
References provided by Crossref.org
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