Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Validation Study
PubMed
21949037
DOI
10.1177/1076029611418961
PII: 1076029611418961
Knihovny.cz E-resources
- MeSH
- Platelet Aggregation drug effects MeSH
- Aspirin pharmacology MeSH
- Time Factors MeSH
- Electric Impedance MeSH
- Hirudins pharmacology MeSH
- Platelet Aggregation Inhibitors pharmacology MeSH
- Cardiovascular Diseases blood MeSH
- Smoking blood MeSH
- Drug Interactions MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Nephelometry and Turbidimetry methods MeSH
- Kidney Diseases blood MeSH
- Obesity blood MeSH
- Area Under Curve MeSH
- Prospective Studies MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Platelet Function Tests methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Validation Study MeSH
- Names of Substances
- Aspirin MeSH
- Hirudins MeSH
- Platelet Aggregation Inhibitors MeSH
BACKGROUND: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term reproducibility (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). METHODS: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67 ± 9 years) on ASA therapy in 10 ± 6 months interval. The STR was assessed in 15 patients (6 females, mean age 61 ± 7 years) with 10 measurements on 2 consecutive days. RESULTS: There was no correlation between both measurements in the long-term part of the study, and also Bland-Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of .800 (P < .05) confirmed by Bland-Altman plot. CONCLUSIONS: Although short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long-term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted.
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