BACKGROUND: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term reproducibility (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). METHODS: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67 ± 9 years) on ASA therapy in 10 ± 6 months interval. The STR was assessed in 15 patients (6 females, mean age 61 ± 7 years) with 10 measurements on 2 consecutive days. RESULTS: There was no correlation between both measurements in the long-term part of the study, and also Bland-Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of .800 (P < .05) confirmed by Bland-Altman plot. CONCLUSIONS: Although short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long-term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted.
- MeSH
- agregace trombocytů účinky léků MeSH
- Aspirin farmakologie MeSH
- časové faktory MeSH
- elektrická impedance MeSH
- hirudiny farmakologie MeSH
- inhibitory agregace trombocytů farmakologie MeSH
- kardiovaskulární nemoci krev MeSH
- kouření krev MeSH
- lékové interakce MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- nefelometrie a turbidimetrie metody MeSH
- nemoci ledvin krev MeSH
- obezita krev MeSH
- plocha pod křivkou MeSH
- prospektivní studie MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- vyšetření funkce trombocytů metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- validační studie MeSH
