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Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment
H. Sevcikova, J. Vojacek, J. Bis, R. Sevcik, J. Maly, M. Pecka, I. Fatorova
Language English Country United States
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Validation Study
Grant support
NR9174
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ProQuest Central
from 1995-01-01
SAGE Publications Journals
from 1999-01-01 to 2015-12-31
Medline Complete (EBSCOhost)
from 1995-01-01
Health & Medicine (ProQuest)
from 1995-01-01
SAGE Journals
from 2012-01-01 to 2012-05-31
ROAD: Directory of Open Access Scholarly Resources
from 1995
- MeSH
- Platelet Aggregation drug effects MeSH
- Aspirin pharmacology MeSH
- Time Factors MeSH
- Electric Impedance MeSH
- Hirudins pharmacology MeSH
- Platelet Aggregation Inhibitors pharmacology MeSH
- Cardiovascular Diseases blood MeSH
- Smoking blood MeSH
- Drug Interactions MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Nephelometry and Turbidimetry methods MeSH
- Kidney Diseases blood MeSH
- Obesity blood MeSH
- Area Under Curve MeSH
- Prospective Studies MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Platelet Function Tests methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Validation Study MeSH
BACKGROUND: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term reproducibility (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). METHODS: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67 ± 9 years) on ASA therapy in 10 ± 6 months interval. The STR was assessed in 15 patients (6 females, mean age 61 ± 7 years) with 10 measurements on 2 consecutive days. RESULTS: There was no correlation between both measurements in the long-term part of the study, and also Bland-Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of .800 (P < .05) confirmed by Bland-Altman plot. CONCLUSIONS: Although short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long-term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted.
References provided by Crossref.org
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- $a Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment / $c H. Sevcikova, J. Vojacek, J. Bis, R. Sevcik, J. Maly, M. Pecka, I. Fatorova
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- $a BACKGROUND: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term reproducibility (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA). METHODS: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67 ± 9 years) on ASA therapy in 10 ± 6 months interval. The STR was assessed in 15 patients (6 females, mean age 61 ± 7 years) with 10 measurements on 2 consecutive days. RESULTS: There was no correlation between both measurements in the long-term part of the study, and also Bland-Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of .800 (P < .05) confirmed by Bland-Altman plot. CONCLUSIONS: Although short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long-term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted.
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