Significantly higher procalcitonin levels could differentiate Gram-negative sepsis from Gram-positive and fungal sepsis
Jazyk angličtina Země Itálie Médium print-electronic
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem
- MeSH
- biologické markery krev MeSH
- C-reaktivní protein analýza MeSH
- diferenciální diagnóza MeSH
- gramnegativní bakteriální infekce diagnóza patologie MeSH
- grampozitivní bakteriální infekce diagnóza patologie MeSH
- kalcitonin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- mykózy diagnóza patologie MeSH
- peptid spojený s genem pro kalcitonin MeSH
- proteinové prekurzory krev MeSH
- retrospektivní studie MeSH
- senioři MeSH
- sepse diagnóza etiologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- CALCA protein, human MeSH Prohlížeč
- kalcitonin MeSH
- peptid spojený s genem pro kalcitonin MeSH
- proteinové prekurzory MeSH
Procalcitonin (PCT) levels can distinguish between infectious and non-infectious systemic inflammatory response. However, there are some differences between Gram-negative (G-), Gram-positive (G+), and fungal bloodstream infections, particularly in different cytokine profiles, severity and mortality. The aim of current study was to examine whether PCT levels can serve as a distinguishing mark between G+, G-, and fungal sepsis as well. One hundred and sixty-six septic patients with positive blood cultures were examined on C-reactive protein (CRP) and PCT on the same date of blood culture evaluation. The median (interquartile range, IQR) of CRP and PCT in G+, G-, and fungal cohorts and comparison of measured values between groups were made using the Kruskal-Wallis test with subsequent Bonferroni's corrections, with p < 0.05. In 83/166 (50 %) of blood cultures, G+ microbes, 78/166 (47 %) G- rods, and 5/166 (3 %) fungi were detected. PCT concentrations (ng/ml) were significantly higher in G- compared to other cohorts: 8.90 (1.88; 32.60) in G-, 0.73 (0.22; 3.40) in G+, and 0.58 (0.35; 0.73) in fungi (p < 0.00001). CRP concentrations did not differ significantly in groups. Significantly higher PCT levels could differentiate G- sepsis from G+ and fungemia. In contrast to CRP, PCT is a good discriminative biomarker in different bloodstream infections.
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