Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
22816377
DOI
10.33549/physiolres.932343
PII: 932343
Knihovny.cz E-resources
- MeSH
- Substance Withdrawal Syndrome etiology metabolism physiopathology MeSH
- Anticonvulsants administration & dosage toxicity MeSH
- Time Factors MeSH
- Quinolizines administration & dosage toxicity MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Brain drug effects metabolism physiopathology MeSH
- Drug Partial Agonism MeSH
- Pentylenetetrazole MeSH
- Rats, Wistar MeSH
- Pyrrolidines administration & dosage toxicity MeSH
- Receptors, GABA-A drug effects metabolism MeSH
- Drug Administration Schedule MeSH
- Carrier Proteins drug effects metabolism MeSH
- Age Factors MeSH
- Seizures chemically induced metabolism physiopathology prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Anticonvulsants MeSH
- Quinolizines MeSH
- Pentylenetetrazole MeSH
- Pyrrolidines MeSH
- Receptors, GABA-A MeSH
- Ro 19-8022 MeSH Browser
- Carrier Proteins MeSH
- Tspo protein, rat MeSH Browser
Repeated administration of partial agonist of benzodiazepine receptors Ro 19-8022 (a derivative of quinolizine class) does not elicit withdrawal in adult rats. Our older data demonstrated that single injection of Ro 19-2088 to immature rats induces increased sensitivity to convulsant action of pentylenetetrazol as a withdrawal phenomenon. To know if repeated administration of the partial agonist has the same effect we injected rats at postnatal days 7 to 11 with an anticonvulsant dose of Ro 19-8022 (0.5 mg/kg i.p.) and tested them 24 h, 48 h and 4 days after the last injection. Repeated administration of Ro 19-8022 resulted also in an increased sensitivity to convulsant action of pentylenetetrazol in immature rats (higher incidence and severity of seizures). This effect was significant 24 h after the last injection but only outlined 48 h after administration. No signs of hypersensitivity were seen at 4-day interval. There is a difference between immature and adult brain in an appearance of withdrawal symptom after administration of the partial agonist of benzodiazepine receptors Ro 19-8022.
References provided by Crossref.org
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