Vascular disturbances in primary aldosteronism: clinical evidence
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
22890049
DOI
10.1159/000340031
PII: 000340031
Knihovny.cz E-zdroje
- MeSH
- cévní rezistence fyziologie MeSH
- hyperaldosteronismus diagnóza epidemiologie patofyziologie MeSH
- hypertenze diagnóza epidemiologie patofyziologie MeSH
- krevní tlak fyziologie MeSH
- lidé MeSH
- nemoci cév diagnóza epidemiologie patofyziologie MeSH
- rychlost toku krve fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance.
Citace poskytuje Crossref.org
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness