Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22985963
DOI
10.1016/j.bmc.2012.08.021
PII: S0968-0896(12)00643-8
Knihovny.cz E-resources
- MeSH
- Antiviral Agents chemical synthesis pharmacology toxicity MeSH
- Hep G2 Cells MeSH
- Hepacivirus drug effects metabolism MeSH
- Indoles chemistry MeSH
- Catalysis MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Palladium MeSH
- Cell Proliferation drug effects MeSH
- Pyrimidines chemistry MeSH
- Virus Replication drug effects MeSH
- Ribonucleosides chemical synthesis pharmacology toxicity MeSH
- Dengue Virus drug effects metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antiviral Agents MeSH
- indole MeSH Browser
- Indoles MeSH
- Palladium MeSH
- pyrimidine MeSH Browser
- Pyrimidines MeSH
- Ribonucleosides MeSH
A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.
References provided by Crossref.org
Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides
Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity
