Health impact of air pollution to children
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23312845
DOI
10.1016/j.ijheh.2012.12.001
PII: S1438-4639(12)00137-X
Knihovny.cz E-resources
- Keywords
- Asthma bronchiale, Carcinogenic polycyclic aromatic hydrocarbons, DNA adducts, Micronuclei, PM2.5, Pregnancy outcome, Respiratory morbidity, Transcriptomics,
- MeSH
- DNA Adducts MeSH
- Child MeSH
- Fetal Blood MeSH
- Infant MeSH
- Air Pollutants toxicity MeSH
- Humans MeSH
- Micronuclei, Chromosome-Defective chemically induced MeSH
- Adolescent MeSH
- Respiratory Tract Diseases epidemiology MeSH
- Infant, Newborn MeSH
- Particulate Matter toxicity MeSH
- Polycyclic Aromatic Hydrocarbons toxicity MeSH
- Child, Preschool MeSH
- Fetal Growth Retardation epidemiology MeSH
- Gene Expression Profiling MeSH
- Pregnancy MeSH
- Air Pollution adverse effects MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- DNA Adducts MeSH
- Air Pollutants MeSH
- Particulate Matter MeSH
- Polycyclic Aromatic Hydrocarbons MeSH
Health impact of air pollution to children was studied over the last twenty years in heavily polluted parts of the Czech Republic during. The research program (Teplice Program) analyzed these effects in the polluted district Teplice (North Bohemia) and control district Prachatice (Southern Bohemia). Study of pregnancy outcomes for newborns delivered between 1994 and 1998 demonstrated that increase in intrauterine growth retardation (IUGR) was associated with PM10 and c-PAHs exposure (carcinogenic polycyclic aromatic hydrocarbons) in the first month of gestation. Morbidity was followed in the cohort of newborns (N=1492) up to the age of 10years. Coal combustion in homes was associated with increased incidence of lower respiratory track illness and impaired early childhood skeletal growth up to the age of 3years. In preschool children, we observed the effect of increased concentrations of PM2.5 and PAHs on development of bronchitis. The Northern Moravia Region (Silesia) is characterized by high concentrations of c-PAHs due to industrial air pollution. Exposure to B[a]P (benzo[a]pyrene) in Ostrava-Radvanice is the highest in the EU. Children from this part of the city of Ostrava suffered higher incidence of acute respiratory diseases in the first year of life. Gene expression profiles in leukocytes of asthmatic children compared to children without asthma were evaluated in groups from Ostrava-Radvanice and Prachatice. The results suggest the distinct molecular phenotype of asthma bronchiale in children living in polluted Ostrava region compared to children living in Prachatice. The effect of exposure to air pollution to biomarkers in newborns was analyzed in Prague vs. Ceske Budejovice, two locations with different levels of pollution in winter season. B[a]P concentrations were higher in Ceske Budejovice. DNA adducts and micronuclei were also elevated in cord blood in Ceske Budejovice in comparison to Prague. Study of gene expression profiles in the cord blood showed differential expression of 104 genes. Specifically, biological processes related to immune and defense response were down-regulated in Ceske Budejovice. Our studies demonstrate that air pollution significantly affect child health. Especially noticeable is the increase of respiratory morbidity. With the development of molecular epidemiology, we can further evaluate the health risk of air pollution using biomarkers.
References provided by Crossref.org
Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children
The Molecular Mechanisms of Adaptive Response Related to Environmental Stress
Impact of Air Pollution on the Health of the Population in Parts of the Czech Republic
