Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23827234
DOI
10.1016/j.bmc.2013.06.011
PII: S0968-0896(13)00542-7
Knihovny.cz E-resources
- Keywords
- Anti-dengue virus activity, Nucleosides, Pyrimido[4,5-b]indoles, Suzuki and Stille cross-coupling,
- MeSH
- Adenosine analogs & derivatives MeSH
- Antiviral Agents chemical synthesis pharmacology toxicity MeSH
- Hep G2 Cells MeSH
- HeLa Cells MeSH
- Hepacivirus drug effects MeSH
- HL-60 Cells MeSH
- Indoles chemistry MeSH
- Catalysis MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Palladium chemistry MeSH
- Ribonucleosides chemistry pharmacology toxicity MeSH
- Cell Survival drug effects MeSH
- Dengue Virus drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine MeSH
- Antiviral Agents MeSH
- indole MeSH Browser
- Indoles MeSH
- Palladium MeSH
- Ribonucleosides MeSH
Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses.
References provided by Crossref.org
Synthesis and Biological Profiling of Quinolino-Fused 7-Deazapurine Nucleosides
Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus
Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity
