HI-6 modulates immunization efficacy in a BALB/c mouse model
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23958973
DOI
10.1016/j.etap.2013.07.012
PII: S1382-6689(13)00159-2
Knihovny.cz E-zdroje
- Klíčová slova
- Acetylcholine receptor, Acetylcholinesterase, Antibody, Cholinergic anti-inflammatory pathway, Inflammation, Vaccine,
- MeSH
- adjuvancia imunologická farmakologie MeSH
- antidota farmakologie MeSH
- ELISA MeSH
- Freundovo adjuvans MeSH
- hemokyanin imunologie MeSH
- imunita účinky léků MeSH
- imunizace * MeSH
- interleukin-6 analýza biosyntéza MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- oximy farmakologie MeSH
- protilátky analýza MeSH
- pyridinové sloučeniny farmakologie MeSH
- rovnováha Th1-Th2 účinky léků MeSH
- tvorba protilátek účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- antidota MeSH
- asoxime chloride MeSH Prohlížeč
- Freundovo adjuvans MeSH
- hemokyanin MeSH
- interleukin-6 MeSH
- keyhole-limpet hemocyanin MeSH Prohlížeč
- oximy MeSH
- protilátky MeSH
- pyridinové sloučeniny MeSH
HI-6 is used as an antidote to nerve agents. It can also act as an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α 7 nAChR which is involved in regulating the immune response through macrophages. This experiment investigated the efficacy of HI-6 to regulate the immune response. Laboratory BALB/c mice received HI-6 and/or keyhole limpet hemocyanin (KLH) as an antigen. Antibody production was investigated after either 21 or 65 days when either single or repeated dose of antigen was applied. We confirmed that HI-6 significantly improved vaccination efficacy when KLH was given in a dose of 1mg/kg. The effect was dose dependent. A combination of HI-6 and KLH produced a vaccination of almost the same efficacy as that for Freund's complete adjuvant. The findings point at the suitability of HI-6 for improving vaccination efficacy at the level of immunity regulation by the nervous system.
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