PAG--a multipurpose transmembrane adaptor protein
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24213579
DOI
10.1038/onc.2013.485
PII: onc2013485
Knihovny.cz E-resources
- MeSH
- CSK Tyrosine-Protein Kinase MeSH
- Phosphorylation MeSH
- Humans MeSH
- Membrane Microdomains metabolism MeSH
- Membrane Proteins chemistry genetics metabolism MeSH
- Actin Cytoskeleton metabolism MeSH
- Neoplasms metabolism MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Signal Transduction MeSH
- src-Family Kinases metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- CSK Tyrosine-Protein Kinase MeSH
- CSK protein, human MeSH Browser
- Membrane Proteins MeSH
- src-Family Kinases MeSH
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.
References provided by Crossref.org
Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice
