Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes
Language English Country United States Media print-electronic
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24705131
DOI
10.1016/j.ajog.2014.03.069
PII: S0002-9378(14)00338-X
Knihovny.cz E-resources
- Keywords
- amniotic fluid, cytokine, histological chorioamnionitis, interleukin-6, microbial invasion of the amniotic fluid,
- MeSH
- Amniocentesis * MeSH
- Biomarkers metabolism MeSH
- Chlamydia trachomatis isolation & purification MeSH
- Chlamydia Infections diagnosis MeSH
- Chorioamnionitis diagnosis metabolism MeSH
- Adult MeSH
- Pregnancy Complications, Infectious diagnosis metabolism MeSH
- Interleukin-6 metabolism MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mycoplasma hominis isolation & purification MeSH
- Mycoplasma Infections diagnosis MeSH
- Amniotic Fluid metabolism microbiology MeSH
- Fetal Membranes, Premature Rupture metabolism MeSH
- Predictive Value of Tests MeSH
- Prospective Studies MeSH
- Sensitivity and Specificity MeSH
- Pregnancy MeSH
- Ureaplasma Infections diagnosis metabolism MeSH
- Point-of-Care Systems * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Interleukin-6 MeSH
OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes.
References provided by Crossref.org
Defining a role for Interferon Epsilon in normal and complicated pregnancies
Cervical Gardnerella vaginalis in women with preterm prelabor rupture of membranes
Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes
Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes
Cervical microbiota in women with preterm prelabor rupture of membranes
