Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem
PubMed
24705131
DOI
10.1016/j.ajog.2014.03.069
PII: S0002-9378(14)00338-X
Knihovny.cz E-zdroje
- Klíčová slova
- amniotic fluid, cytokine, histological chorioamnionitis, interleukin-6, microbial invasion of the amniotic fluid,
- MeSH
- amniocentéza * MeSH
- biologické markery metabolismus MeSH
- Chlamydia trachomatis izolace a purifikace MeSH
- chlamydiové infekce diagnóza MeSH
- chorioamnionitida diagnóza metabolismus MeSH
- dospělí MeSH
- infekční komplikace v těhotenství diagnóza metabolismus MeSH
- interleukin-6 metabolismus MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Mycoplasma hominis izolace a purifikace MeSH
- mykoplazmové infekce diagnóza MeSH
- plodová voda metabolismus mikrobiologie MeSH
- předčasný odtok plodové vody metabolismus MeSH
- prediktivní hodnota testů MeSH
- prospektivní studie MeSH
- senzitivita a specificita MeSH
- těhotenství MeSH
- ureaplasmatické infekce diagnóza metabolismus MeSH
- vyšetření u lůžka * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- interleukin-6 MeSH
OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes.
Citace poskytuje Crossref.org
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Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes
Intraamniotic Inflammation in Women with Preterm Prelabor Rupture of Membranes
Cervical microbiota in women with preterm prelabor rupture of membranes
