Mechanosensors in integrin signaling: the emerging role of p130Cas
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
25062607
DOI
10.1016/j.ejcb.2014.07.002
PII: S0171-9335(14)00067-3
Knihovny.cz E-resources
- Keywords
- Focal adhesions, Integrins, Mechanosensing, Podosomes, p130Cas,
- MeSH
- Cell Surface Extensions metabolism MeSH
- Mechanotransduction, Cellular physiology MeSH
- Focal Adhesions metabolism MeSH
- Integrins metabolism MeSH
- Humans MeSH
- Stress, Mechanical MeSH
- Actin Cytoskeleton metabolism MeSH
- Crk-Associated Substrate Protein metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Integrins MeSH
- Crk-Associated Substrate Protein MeSH
Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases.
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