Mechanosensors in integrin signaling: the emerging role of p130Cas
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
25062607
DOI
10.1016/j.ejcb.2014.07.002
PII: S0171-9335(14)00067-3
Knihovny.cz E-zdroje
- Klíčová slova
- Focal adhesions, Integrins, Mechanosensing, Podosomes, p130Cas,
- MeSH
- buněčné výběžky metabolismus MeSH
- buněčný převod mechanických signálů fyziologie MeSH
- fokální adheze metabolismus MeSH
- integriny metabolismus MeSH
- lidé MeSH
- mechanický stres MeSH
- mikrofilamenta metabolismus MeSH
- substrátový protein asociovaný s Crk metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- integriny MeSH
- substrátový protein asociovaný s Crk MeSH
Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases.
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