Vimentin Intermediate Filaments as Potential Target for Cancer Treatment
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články, přehledy
Grantová podpora
18-15684J
Grantová Agentura České Republiky
19-03932S
Grantová Agentura České Republiky
17-31538A
Grantová Agentura České Republiky
LQ1604
Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/0.0/16_019/ 0000785
Ministerstvo Zdravotnictví Ceské Republiky
LTC17063
European Cooperation in Science and Technology
PubMed
31940801
PubMed Central
PMC7017239
DOI
10.3390/cancers12010184
PII: cancers12010184
Knihovny.cz E-zdroje
- Klíčová slova
- EMT, amoeboid, cancer drugs, cancer treatment, cell adhesion, invasion, mechanotransduction, mesenchymal, vimentin,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing distinct expression patterns in tissues and cell types. Changes in the expression patterns of intermediate filaments are often associated with cancer progression; in particular with phenotypes leading to increased cellular migration and invasion. In this review we will describe the role of vimentin intermediate filaments in cancer cell migration, cell adhesion structures, and metastasis formation. The potential for targeting vimentin in cancer treatment and the development of drugs targeting vimentin will be reviewed.
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Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks
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