Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
25194136
DOI
10.33549/physiolres.932823
PII: 932823
Knihovny.cz E-zdroje
- MeSH
- adipozita MeSH
- desmogleiny genetika MeSH
- energetický metabolismus * genetika MeSH
- fenotyp MeSH
- fyziologická adaptace MeSH
- genotyp MeSH
- glukosa metabolismus MeSH
- hnědá tuková tkáň metabolismus patofyziologie MeSH
- hypertenze genetika metabolismus patofyziologie MeSH
- inzulin metabolismus MeSH
- kosterní svaly metabolismus patofyziologie MeSH
- kyselina palmitová metabolismus MeSH
- modely nemocí na zvířatech MeSH
- mutace MeSH
- nízká teplota * MeSH
- oxidace-redukce MeSH
- potkani bezsrstí MeSH
- potkani inbrední SHR MeSH
- přijímání potravy MeSH
- regulace genové exprese MeSH
- sexuální faktory MeSH
- termogeneze * genetika MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- desmogleiny MeSH
- Dsg4 protein, rat MeSH Prohlížeč
- glukosa MeSH
- inzulin MeSH
- kyselina palmitová MeSH
Cold exposure of rats leads to ameliorated glucose and triglyceride utilization with females displaying better adaptation to a cold environment. In the current study, we used hairless rats as a model of increased thermogenesis and analyzed gender-related effects on parameters of lipid and glucose metabolism in the spontaneously hypertensive (SHR) rats. Specifically, we compared hairless coisogenic SHR-Dsg4 males and females harboring mutant Dsg4 (desmoglein 4) gene versus their SHR wild type controls. Two way ANOVA showed significant Dsg4 genotype (hairless or wild type) x gender interaction effects on palmitate oxidation in brown adipose tissue (BAT), glucose incorporation into BAT determined by microPET, and glucose oxidation in skeletal muscles. In addition, we observed significant interaction effects on sensitivity of muscle tissue to insulin action when Dsg4 genotype affected these metabolic traits in males, but had little or no effects in females. Both wild type and hairless females and hairless males showed increased glucose incorporation and palmitate oxidation in BAT and higher tissue insulin sensitivity when compared to wild type males. These findings provide evidence for gender-related differences in metabolic adaptation required for increased thermogenesis. They are consistent with the hypothesis that increased glucose and palmitate utilization in BAT and muscle is associated with higher sensitivity of adipose and muscle tissues to insulin action.
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