Isolated heart models: cardiovascular system studies and technological advances
Language English Country United States Media print-electronic
Document type Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Biomedical Research * history methods MeSH
- History, 19th Century MeSH
- History, 20th Century MeSH
- History, 21st Century MeSH
- Rats MeSH
- Humans MeSH
- Models, Cardiovascular * MeSH
- Mice MeSH
- Perfusion MeSH
- Heart * anatomy & histology physiology MeSH
- Anura MeSH
- Animals MeSH
- Check Tag
- History, 19th Century MeSH
- History, 20th Century MeSH
- History, 21st Century MeSH
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Historical Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.
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