Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- aktivace enzymů MeSH
- apoptóza * MeSH
- exprese genu MeSH
- kaspasa 3 metabolismus MeSH
- kaspasa 7 nedostatek genetika metabolismus MeSH
- kaspasy genetika metabolismus MeSH
- kůže embryologie metabolismus MeSH
- mastocyty metabolismus MeSH
- myši knockoutované MeSH
- myši MeSH
- počet buněk MeSH
- transport proteinů MeSH
- vlasový folikul embryologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kaspasa 3 MeSH
- kaspasa 7 MeSH
- kaspasy MeSH
Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
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