Anti-tumour necrosis factor treatment of severe psoriasis complicated by Epstein-Barr Virus hepatitis and subsequently by chronic hepatitis
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article
PubMed
26278774
DOI
10.1111/dth.12271
Knihovny.cz E-resources
- Keywords
- biologic therapy, hepatitis Epstein-Barr virus, psoriasis,
- MeSH
- Antiviral Agents therapeutic use MeSH
- Biopsy MeSH
- Hepatitis, Chronic diagnosis drug therapy immunology virology MeSH
- Immunocompromised Host * MeSH
- Immunologic Factors adverse effects MeSH
- Remission Induction MeSH
- Epstein-Barr Virus Infections diagnosis drug therapy immunology virology MeSH
- Infliximab adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Opportunistic Infections diagnosis drug therapy immunology virology MeSH
- Alcohol Drinking adverse effects MeSH
- Psoriasis diagnosis drug therapy immunology MeSH
- Risk Factors MeSH
- Severity of Illness Index MeSH
- Tumor Necrosis Factor-alpha antagonists & inhibitors immunology MeSH
- Hepatitis, Viral, Human diagnosis drug therapy immunology virology MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Antiviral Agents MeSH
- Immunologic Factors MeSH
- Infliximab MeSH
- Tumor Necrosis Factor-alpha MeSH
A case is described of severe acute hepatitis in 47-year-old woman with chronic psoriasis and psoriatic arthritis treated with infliximab. Although clinical, serological and laboratory results were compatible with acute EBV hepatitis, it was difficult to differentiate between EBV infection and other non-infectious causes of hepatitis. The patient gradually developed chronic hepatitis with liver steatosis and efficient treatment with adalimumab had to be stopped. This case presents an uncommon complication that may arise from the use of biologic therapy and calls for caution in long-term management of psoriatic patients with internal comorbidities.
References provided by Crossref.org
