Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26365933
DOI
10.5507/bp.2015.037
Knihovny.cz E-resources
- Keywords
- apolipoproteins D, apolipoproteins E, asymmetric dimethylarginine, in-stent restenosis, lecitin-cholesterol acyltransferase, matrix metalloproteinases, myeloperoxidase,
- MeSH
- Apolipoproteins D metabolism MeSH
- Apolipoproteins E metabolism MeSH
- Arginine analogs & derivatives metabolism MeSH
- Biomarkers metabolism MeSH
- Percutaneous Coronary Intervention MeSH
- Coronary Restenosis diagnosis physiopathology MeSH
- Phosphatidylcholine-Sterol O-Acyltransferase metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipoprotein(a) metabolism MeSH
- Matrix Metalloproteinase 3 metabolism MeSH
- Matrix Metalloproteinase 9 metabolism MeSH
- Graft Occlusion, Vascular diagnosis physiopathology MeSH
- Peroxidase metabolism MeSH
- Vascular Patency physiology MeSH
- Aged MeSH
- Stents * MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Apolipoproteins D MeSH
- Apolipoproteins E MeSH
- Arginine MeSH
- Biomarkers MeSH
- Phosphatidylcholine-Sterol O-Acyltransferase MeSH
- Lipoprotein(a) MeSH
- Matrix Metalloproteinase 3 MeSH
- Matrix Metalloproteinase 9 MeSH
- N,N-dimethylarginine MeSH Browser
- Peroxidase MeSH
AIMS: We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting. METHODS: A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT). Multivariable logistic regression association tests were performed. RESULTS: Increased plasma MMP-3 (OR: 1.013; 95% CI: 1.004-1.023; P = 0.005), MMP-9 (OR: 1.014; 95% CI: 1.008-1.020; P < 0.0001) or MPO (OR: 1,003; 95% CI: 1.001-1.005; P = 0.002) was significantly associated with increased risk of ISR. Increased levels of ADMA (OR: 0.212; 95% CI: 0.054-0.827; P = 0.026), ApoE (OR: 0.924; 95% CI: 0.899-0.951; P < 0.0001), ApoD (OR: 0.919; 95% CI: 0.880-0.959; P = 0.0001), or LCAT (OR: 0.927; 95% CI: 0.902-0.952; P < 0.0001) was associated with risk reduction. No correlation was found between plasma MMP-2 or Lp (a) and ISR risk. CONCLUSIONS: Increased levels of MMP-3, MMP-9, and MPO represent predictors of ISR after bare-metal stent implantation. In contrast, increased ADMA, LCAT, and Apo E and D indicate a decreased in-stent restenosis occurrence.
Blood Center University Hospital of Ostrava
Department of Biomedical Sciencies Faculty of Medicine University of Ostrava
Department of Cardiovascular Diseases University Hospital Ostrava
Department of Clinical Studies Faculty of Medicine University of Ostrava Czech Republic
Department of Laboratory Medicine University Hospital Ostrava
Department of Medical Biophysics Faculty of Medicine and Dentistry Palacky University Olomouc
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