Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider(TM) technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile of incorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences of the molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct - the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers.

Department of Analytical Chemistry Faculty of Science Charles University Prague Albertov 2030 128 43 Prague 2 Czech Republic

Nanovia Ltd Podkrusnohorska 271 436 03 Litvinov Chuderin Czech Republic

The Institute of Macromolecular Chemistry Academy of Sciences of the Czech Republic Heyrovsky Sq 2 162 06 Prague 6 Czech Republic

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Langer R, Peppas N A. AIChE J. 2003;49:2990–3006. doi: 10.1002/aic.690491202. DOI

Geipel A, Goldschmidtboeing F, Jantscheff P, Esser N, Massing U, Woias P. Biomed Microdevices. 2008;10:469–478. doi: 10.1007/s10544-007-9147-2. PubMed DOI

Nagy Zs K, Nyúl K, Wagner I, Molnár K, Marosi Gy. eXPRESS Polym Lett. 2010;4:763–772. doi: 10.3144/expresspolymlett.2010.92. DOI

Ahmed I, Ponery A S, Nur-E-Kamal A, Kamal J, Meshel A S, Sheetz M P, Schindler M, Meiners S. Mol Cell Biochem. 2007;301:241–249. doi: 10.1007/s11010-007-9417-6. PubMed DOI

Shih Y-R V, Chen C-N, Tsai S-W, Wang Y J, Lee O K. Stem Cells. 2006;24:2391–2397. doi: 10.1634/stemcells.2006-0253. PubMed DOI

Barnes C P, Sell S A, Boland E D, Simpson D G, Bowlin G L. Adv Drug Delivery Rev. 2007;59:1413–1433. doi: 10.1016/j.addr.2007.04.022. PubMed DOI

Rieger K A, Birch N P, Schiffman J D. J Mater Chem B. 2013;1:4531–4541. doi: 10.1039/c3tb20795a. PubMed DOI

Leung V, Ko F. Polym Adv Technol. 2011;22:350–365. doi: 10.1002/pat.1813. DOI

Jayaraman K, Kotaki M, Zhang Y, Mo X, Ramakrishna S. J Nanosci Nanotechnol. 2004;4:52–65. doi: 10.1166/jnn.2004.078. PubMed DOI

Huang Z-M, Zhang Y-Z, Kotaki M, Ramakrishna S. Compos Sci Technol. 2003;63:2223–2253. doi: 10.1016/S0266-3538(03)00178-7. DOI

Luo C J, Stoyanov S D, Stride E, Pelan E, Edirisinghe M. Chem Soc Rev. 2012;41:4708–4735. doi: 10.1039/c2cs35083a. PubMed DOI

Bellan L M, Craighead H G. Polym Adv Technol. 2011;22:304–309. doi: 10.1002/pat.1790. DOI

Sun B, Long Y Z, Zhang H D, Li M M, Duvail J L, Jiang X Y, Yin H L. Prog Polym Sci. 2014;39:862–890. doi: 10.1016/j.progpolymsci.2013.06.002. DOI

Bhardwaj N, Kundu S C. Biotechnol Adv. 2010;28:325–347. doi: 10.1016/j.biotechadv.2010.01.004. PubMed DOI

Thompson C J, Chase G G, Yarin A L, Reneker D H. Polymer. 2007;48:6913–6922. doi: 10.1016/j.polymer.2007.09.017. DOI

Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X. J Controlled Release. 2014;185:12–21. doi: 10.1016/j.jconrel.2014.04.018. PubMed DOI

Persano L, Camposeo A, Tekmen C, Pisignano D. Macromol Mater Eng. 2013;298:504–520. doi: 10.1002/mame.201200290. DOI

Jirsak O, Sanetrnik F, Lukas D, Kotek L, Martinova L, Chaloupek J, inventors. Method of nanofibers production from polymer solution using electrostatic spinning and a device for carrying out the method. 20060290031. U.S. Patent. 2006

Lukas D, Sarkar A, Pokorny P. J Appl Phys. 2008;103:084309. doi: 10.1063/1.2907967. DOI

Ryu Y J, Kim H Y, Lee K H, Park H C, Lee D R. Eur Polym J. 2003;39:1883–1889. doi: 10.1016/S0014-3057(03)00096-X. DOI

Xu X, Chen X, Ma P, Wang X, Jing X. Eur J Pharm Biopharm. 2008;70:165–170. doi: 10.1016/j.ejpb.2008.03.010. PubMed DOI

Jiang H, Wang L, Zhu K. J Controlled Release. 2014;193:296–303. doi: 10.1016/j.jconrel.2014.04.025. PubMed DOI

Son Y J, Kim W J, Yoo H S. Arch Pharmacal Res. 2014;37:69–78. doi: 10.1007/s12272-013-0284-2. PubMed DOI

Saraf A, Baggett L S, Raphael R M, Kasper F K, Mikos A G. J Controlled Release. 2010;143:95–103. doi: 10.1016/j.jconrel.2009.12.009. PubMed DOI PMC

Steele T W J, Huang C L, Widjaja E, Boey F Y C, Loo J S C, Venkatraman S S. Acta Biomater. 2011;7:1973–1983. doi: 10.1016/j.actbio.2011.02.002. PubMed DOI

Herrmann S, Winter G, Mohl S, Siepmann F, Siepmann J. J Controlled Release. 2007;118:161–168. doi: 10.1016/j.jconrel.2006.11.001. PubMed DOI

Sirc J, Kubinova S, Hobzova R, Stranska D, Kozlík P, Bosakova Z, Marekova D, Holan V, Sykova E, Michalek J. Int J Nanomed. 2012;7:5315–5325. doi: 10.2147/IJN.S35781. PubMed DOI PMC

Širc J, Hobzová R, Kostina N, Munzarová M, Juklíčková M, Lhotka M, Kubinová Š, Zajícová A, Michálek J. J Nanomater. 2012:No. 327369. doi: 10.1155/2012/327369. DOI

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