Cytocompatibility of amine functionalized carbon nanoparticles grafted on polyethylene
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26706545
DOI
10.1016/j.msec.2015.11.058
PII: S0928-4931(15)30589-0
Knihovny.cz E-resources
- Keywords
- Carbon nanoparticles, Cytocompatibility, Nanoparticles characterization, Surface amine functionalization, Surface characterization,
- MeSH
- Amines chemistry MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Myocytes, Smooth Muscle cytology drug effects MeSH
- Nanoparticles adverse effects chemistry MeSH
- Polyethylene chemistry MeSH
- Cell Proliferation drug effects MeSH
- Wettability MeSH
- Muscle, Smooth, Vascular cytology MeSH
- Carbon chemistry MeSH
- Cell Survival drug effects MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amines MeSH
- Polyethylene MeSH
- Carbon MeSH
Five types of amide-amine Carbon Nano-Particles (CNPs) were prepared by functionalization of CNPs and characterized by several analytical methods. The successful grafting of amines on CNPs was verified by X-ray photoelectron spectroscopy (XPS), organic elemental analysis and electrokinetic analysis. The size and morphology of CNPs were determined from transmission electron microscopy. The surface area and porosity of CNPs were examined by adsorption and desorption isotherms. Differential scanning calorimetry was used to investigate thermal stability of CNPs. The amount of bonded amine depends on its dimensionality arrangement. Surface area and pore volumes of CNPs decrease several times after individual amino-compound grafting. Selected types of functionalized CNPs were grafted onto a plasma activated surface of HDPE. The successful grafting of CNPs on the polymer surface was verified by XPS. Wettability was determined by contact angle measurements. Surface morphology and roughness were studied by atomic force microscopy. A dramatic decrease of contact angle and surface morphology was observed on CNP grafted polymer surface. Cytocompatibility of modified surfaces was studied in vitro, by determination of adhesion, proliferation and viability of vascular smooth muscle cells (VSMCs). Grafting of CNPs onto the polymer surface has a positive effect on the adhesion, proliferation and viability of VSMCs.
References provided by Crossref.org
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