INTRODUCTION: Impaired baroreflex function is associated with a shift in autonomic balance towards sympathetic dominance, which may play important role in the development of arterial hypertension and consequent target organ damage. AIM: To determine the effect of treatment on the cardiovascular autonomic modulation expressed by baroreflex sensitivity (BRS) in hypertensives. METHODS: A total of one hundred fourteen hypertensive patients (58 male/56 female, 65 ± 13 years of age, BMI 30 ± 3.4 kg/m(2)) were enrolled. Control group of 20 subjects with normal blood pressure (BP) (ten male/ten female, 59 ± 8 years of age, body mass index 28.3 ± 2.5 kg/m(2)) without any treatment was also studied. BRS and BRSf were determined by the sequence and spectral method: a 5-min on-invasive beat-to-beat recording of blood pressure and R-R interval with use of Collin CBM-7000 monitor, controlled breathing at a frequency of 0.1 Hz. RESULTS: Significant negative correlation between spontaneous BRS and BP was present in hypertensives (r = -0.52, p < 0.001). All cohort of hypertensive patients had significantly lower BRS than subjects with normal blood pressure (p < 0.05). The greatest decline in BRS values was in hypertensive patients with metabolic syndrome, who had BRS values <5 ms/mmHg. Hypertensives with hypercholesterolaemia on low dose statin therapy (atrovastatin 20 mg) had higher BRS/BRSf values than statin free patients (p < 0.05). Only BRSf not BRS was significantly increased in hypertensives with beta-blockers. CONCLUSION: An inverse correlation between blood pressure and BRS is present in hypertensives. BRS and BRSf is higher in low dose statin-treated patients with essential hypertension.

2nd Department of Internal Medicine Faculty of Medicine Comenius University and University Hospital Mickiewiczova 13 813 69 Bratislava Slovak Republic

Department of Cardiology East Slovak Institute of Cardiovascular Disease Pavol Jozef Safarik University Kosice Slovak Republic

Department Pharmacology and Clinical Pharmacology Medical Faculty Medical University of Plovdiv Plovdiv Bulgaria

Institute of Histology and Embryology Faculty of Medicine University in Ljubljana Vrazov trg 2 Ljubljana Slovenia

International Center for Cardiovascular Diseases Medicor Ljubljana Slovenia

Laboratory of Structural Biology and Proteomics Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Palackeho tr 1 1946 613 00 Brno Czech Republic

School of Medicine University of Oviedo and Central University Hospital of Asturias Oviedo Asturias Spain

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