Matrix Gla protein jako přirozený inhibitor vaskulárních kalcifikací a potenciální léčebný cíl
[Matrix Gla protein as natural inhibitor of vascular calcification and potential treatment target]
Language Czech Country Czech Republic Media print
Document type Journal Article, Review
PubMed
27481196
PII: 58600
- Keywords
- cardiovascular diseases., matrix Gla protein, vascular calcifications, vitamin K,
- MeSH
- Antifibrinolytic Agents therapeutic use MeSH
- Extracellular Matrix Proteins therapeutic use MeSH
- Humans MeSH
- Matrix Gla Protein MeSH
- Dietary Supplements MeSH
- Calcium-Binding Proteins therapeutic use MeSH
- Risk Factors MeSH
- Vascular Calcification prevention & control MeSH
- Vitamin K therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Antifibrinolytic Agents MeSH
- Extracellular Matrix Proteins MeSH
- Calcium-Binding Proteins MeSH
- Vitamin K MeSH
Vascular calcification was once regarded as an advanced stage of atherosclerosis only. However, calcification is currently considered as highly regulated and potentially reversible process.Matrix Gla protein (MGP) represents natural inhibitor of vascular calcification, whereas vitamin K is key co-factor of its maturation to the active form. There is accumulating evidence that vitamin K status and corresponding MGP activity may influence cardiovascular risk. This review summarizes pathophysiological mechanism and recent evidence relative to MGP. Moreover, available data concerning vitamin K supplementation are depicted.
