Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- Klíčová slova
- Colorectal cancer, Polymorphism, Risk factors, SNP, miRNA target site, miRSNP,
- MeSH
- 3' nepřekládaná oblast genetika MeSH
- celogenomová asociační studie MeSH
- epigeneze genetická MeSH
- genetická predispozice k nemoci MeSH
- interakce genů a prostředí MeSH
- jednonukleotidový polymorfismus * MeSH
- kokarcinogeneze MeSH
- kolorektální nádory diagnóza epidemiologie genetika MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- nekódující RNA genetika MeSH
- polyadenylace MeSH
- prognóza MeSH
- progrese nemoci MeSH
- regulace genové exprese u nádorů genetika MeSH
- rizikové faktory MeSH
- RNA nádorová genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- 3' nepřekládaná oblast MeSH
- mikro RNA MeSH
- nekódující RNA MeSH
- RNA nádorová MeSH
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors in interplay with epigenetic mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genome-wide association studies (GWAS) that allowed the discovery of several genetic regions and variants associated with weak effects on sporadic CRC. Collectively these variants may enable a more accurate prediction of an individual's risk to the disease and its prognosis. However, the number of variants contributing to CRC is still not fully explored.SNPs in genes encoding the miRNA sequence or in 3'UTR regions of the corresponding binding sites may affect miRNA transcription, miRNA processing, and/or the fidelity of the miRNA-mRNA interaction. These variants could plausibly impact miRNA expression and target mRNA translation into proteins critical for cellular integrity, differentiation, and proliferation.In the present chapter, we describe the different aspects of variations related to miRNAs and other non-coding RNAs (ncRNAs) and evidence from studies investigating these candidate genetic alterations in support to their role in CRC development and progression.
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