Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- Keywords
- Colorectal cancer, Polymorphism, Risk factors, SNP, miRNA target site, miRSNP,
- MeSH
- 3' Untranslated Regions genetics MeSH
- Genome-Wide Association Study MeSH
- Epigenesis, Genetic MeSH
- Genetic Predisposition to Disease MeSH
- Gene-Environment Interaction MeSH
- Polymorphism, Single Nucleotide * MeSH
- Cocarcinogenesis MeSH
- Colorectal Neoplasms diagnosis epidemiology genetics MeSH
- Humans MeSH
- MicroRNAs genetics MeSH
- RNA, Untranslated genetics MeSH
- Polyadenylation MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Gene Expression Regulation, Neoplastic genetics MeSH
- Risk Factors MeSH
- RNA, Neoplasm genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- 3' Untranslated Regions MeSH
- MicroRNAs MeSH
- RNA, Untranslated MeSH
- RNA, Neoplasm MeSH
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors in interplay with epigenetic mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genome-wide association studies (GWAS) that allowed the discovery of several genetic regions and variants associated with weak effects on sporadic CRC. Collectively these variants may enable a more accurate prediction of an individual's risk to the disease and its prognosis. However, the number of variants contributing to CRC is still not fully explored.SNPs in genes encoding the miRNA sequence or in 3'UTR regions of the corresponding binding sites may affect miRNA transcription, miRNA processing, and/or the fidelity of the miRNA-mRNA interaction. These variants could plausibly impact miRNA expression and target mRNA translation into proteins critical for cellular integrity, differentiation, and proliferation.In the present chapter, we describe the different aspects of variations related to miRNAs and other non-coding RNAs (ncRNAs) and evidence from studies investigating these candidate genetic alterations in support to their role in CRC development and progression.
References provided by Crossref.org
