Alarmins and Clinical Outcomes After Major Abdominal Surgery-A Prospective Study
Language English Country United States Media print-electronic
Document type Journal Article, Observational Study
- Keywords
- alarmins, damage-associated molecular patterns, gastrointestinal resection, major abdominal surgery, outcome, surgical injury,
- MeSH
- Alarmins blood MeSH
- Abdomen surgery MeSH
- Digestive System Surgical Procedures mortality MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasms blood surgery MeSH
- Prospective Studies MeSH
- HMGB1 Protein blood MeSH
- S100 Proteins blood MeSH
- HSP70 Heat-Shock Proteins blood MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Alarmins MeSH
- HMGB1 protein, human MeSH Browser
- HMGB1 Protein MeSH
- S100 Proteins MeSH
- HSP70 Heat-Shock Proteins MeSH
- S100A1 protein MeSH Browser
PURPOSE: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes. MATERIALS AND METHODS: We analyzed serum levels of alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, and S100A12; high-mobility group box 1; and heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days after surgery. The goals were to evaluate the relationships among the serum levels of alarmins and selected surgical characteristics and to test potential of alarmins to predict the clinical outcomes. RESULTS: Significant, positive correlations were found for high-mobility group box 1 with the length of surgery, blood loss, and intraoperative fluid intake for all three days of blood sampling. The protein S100A8 serum levels showed positive correlations with intensive care unit length of stay, 28-day and in-hospital mortality. The protein S100A12 serum levels had significant, positive correlations with intensive care unit length of stay, 28-day mortality, and in-hospital mortality. We did not find significant differences in alarmin levels between cancer and noncancer subjects. CONCLUSION: The high-mobility group box 1 serum levels reflect the degree of surgical injury, whereas proteins S100A8 and S100A12 might be considered good predictors of major abdominal surgery morbidity and mortality.
b University Hospital of Ostrava Ostrava Czech Republic
e Military Hospital of Prague Prague Czech Republic
University of Ostrava Ostrava Czech Republic
Univerzita Karlova Praha 1st Faculty Of Medicine Praha Czech Republic
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