High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
27762584
DOI
10.33549/physiolres.933420
PII: 933420
Knihovny.cz E-zdroje
- MeSH
- antitumorózní látky * MeSH
- methakryláty * MeSH
- micely MeSH
- nanočástice MeSH
- nosiče léků * MeSH
- polymery * MeSH
- prekurzory léčiv MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antitumorózní látky * MeSH
- hydroxypropyl methacrylate MeSH Prohlížeč
- methakryláty * MeSH
- micely MeSH
- nosiče léků * MeSH
- polymery * MeSH
- prekurzory léčiv MeSH
In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl)methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.
Citace poskytuje Crossref.org
Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models
HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study
