Recent advances in CE-MS coupling: Instrumentation, methodology, and applications
Language English Country Germany Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
- Keywords
- CE, Electrospray, MS, Microfluidic devices,
- MeSH
- Single-Cell Analysis methods MeSH
- Food Analysis methods MeSH
- Biomarkers analysis MeSH
- Cell Line MeSH
- Chromatography methods MeSH
- Electrophoresis, Capillary instrumentation methods MeSH
- Glycomics MeSH
- Spectrometry, Mass, Electrospray Ionization instrumentation methods MeSH
- Mass Spectrometry methods MeSH
- Isoelectric Focusing instrumentation methods MeSH
- Lab-On-A-Chip Devices * MeSH
- Humans MeSH
- Metabolomics methods MeSH
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization instrumentation methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Biomarkers MeSH
This review focuses on the latest development of microseparation electromigration methods in capillaries and microfluidic devices coupled with MS for detection and identification of important analytes. It is a continuation of the review article on the same topic by Kleparnik (Electrophoresis 2015, 36, 159-178). A wide selection of 161 relevant articles covers the literature published from June 2014 till May 2016. New improvements in the instrumentation and methodology of MS interfaced with capillary or microfluidic versions of zone electrophoresis, isotachophoresis, and isoelectric focusing are described in detail. The most frequently implemented MS ionization methods include electrospray ionization, matrix-assisted desorption/ionization and inductively coupled plasma ionization. Although the main attention is paid to the development of instrumentation and methodology, representative examples illustrate also applications in the proteomics, glycomics, metabolomics, biomarker research, forensics, pharmacology, food analysis, and single-cell analysis. The combinations of MS with capillary versions of electrochromatography, and micellar electrokinetic chromatography are not included.
References provided by Crossref.org
Peptidomics and Capillary Electrophoresis
Microfluidics for Peptidomics, Proteomics, and Cell Analysis
