Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
28232134
DOI
10.1016/j.neulet.2017.02.043
PII: S0304-3940(17)30159-3
Knihovny.cz E-zdroje
- Klíčová slova
- Cortical epileptic afterdischarges, Immature rats, Lithium chloride, Paraldehyde, Pilocarpine, Status epilepticus,
- MeSH
- antikonvulziva farmakologie MeSH
- chlorid lithný farmakologie MeSH
- konvulziva farmakologie MeSH
- krysa rodu Rattus MeSH
- modely nemocí na zvířatech MeSH
- mozková kůra účinky léků MeSH
- paraldehyd farmakologie MeSH
- pilokarpin farmakologie MeSH
- potkani Wistar MeSH
- status epilepticus chemicky indukované MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antikonvulziva MeSH
- chlorid lithný MeSH
- konvulziva MeSH
- paraldehyd MeSH
- pilokarpin MeSH
Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naïve animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to naïve control with a progressive prolongation of CxAD. LiCl group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium and paraldehyde are similar to naïve controls.
Citace poskytuje Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
The outcome of early life status epilepticus-lessons from laboratory animals
